IL‐33 citrine reporter mice reveal the temporal and spatial expression of IL‐33 during allergic lung inflammation
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چکیده
منابع مشابه
IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation
Interleukin-33 (IL-33) is an IL-1 family cytokine that signals via its receptor T1/ST2, and is a key regulator of inflammation, notably the type-2 response implicated in allergic asthma. Critical to our understanding of the role of IL-33 is the identification of the cellular sources of IL-33. Although progress has been made in this area, the development of a robust live cell reporter of express...
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BACKGROUND Interleukin-33 (IL-33) has recently been implicated in tumor development. METHODS Data was obtained from PubMed, EMBASE, Clinical trial, Cochrane Library, Web of Science, CNKI and Wanfang databases. After quality assessment and data extraction, a meta-analysis was performed using Review Manager 5. 2 software. RESULTS There were eight documents included in this meta-analysis. The ...
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BACKGROUND & AIMS Interleukin (IL)33 is a recently described alarmin that is highly expressed in the gastric mucosa and potently activates Th2 immunity. It may play a pivotal role during Helicobacter pylori infection. Here, we delineate the role of IL33 in the normal gastric mucosa and in response to gastropathy. METHODS IL33 expression was evaluated in mice and human biopsy specimens infecte...
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IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma. Through whole-genome sequencing and imputation into the Icelandic population, we found a rare variant in IL33 (NM_0...
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BACKGROUND The immunosuppression and immune dysregulation that follows severe injury includes type 2 immune responses manifested by elevations in interleukin (IL) 4, IL5, and IL13 early after injury. We hypothesized that IL33, an alarmin released early after tissue injury and a known regulator of type 2 immunity, contributes to the early type 2 immune responses after systemic injury. METHODS ...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2012
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.201242863